Cancer Exosomes: An Overview and the Applications of Flow

Cancer is one of the most prevalent and disruptive diseases affecting population, as such, subject major research efforts. Recently, these efforts have been put towards understanding role that exosomes can play in progression cancer. Exosomes are small extracellular vesicles ranging from 40–150 nm size carry bioactive molecules like proteins, DNA, RNA, miRNA, surface receptors. One important features their ability to easily travel throughout body, extending reach parent cell’s signaling capabilities. derived (CDEs) dangerous cargo aid metastasis, disease through angiogenesis, promoting epithelial mesenchymal transition, immune suppression. transport cells tumor environment well distant premetastatic locations making them an extremely versatile tool toolbelt This review aims compile present knowledge involvement cancer current production, isolation, purification methods, with particular interest on flow perfusion bioreactor microfluidics systems, which allow for accurate modeling production exosomes.